Just accepted in Human Molecular Genetics, a really interesting report on how variants in ATP13a2 (a gene involved in a rare inherited form of early onset parkinsonism called Kufor Rakeb Syndrome, or KRS) can influence the probability that a mutation in LRRK2 will cause disease. The study, led by Huw Morris at the UCL Institute of Neurology, is one of the first to show precise evidence of oligogenic inheritance in Parkinson’s, where more than one gene is influencing disease onset. Intriguingly, a parallel study using a different approach by Matt Farrer from the University of British Columbia identifies another gene, DNM3, as having a similar role. There is also an interesting editorial in Lancet Neurology about this. If you want to read more about the HMG study (which myself and James Tomkins, a PhD student in the lab, where involved in), click on the link below.