Is synuclein different in LRRK2 mutation cases?

We’ve been looking at the biochemical characteristics of alpha synuclein in the brains of LRRK2 mutation carriers, with some surprising results. The synuclein in LRRK2 G2019S brains seems to be more soluble than that in idiopathic PD – which could have some important implications for what LRRK2 is doing in PD.

See our paper in Neurobiology of Disease for more details:

http://dx.doi.org/10.1016/j.nbd.2013.05.017

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