Myself, Rina Bandopadhyay, Jack Brelstaff and Claire Hall are attending the European Society for Neurochemistry meeting at the University of Bath. It is focused on the molecular mechanisms underlying neurodegenerative diseases, and there are lots of interesting speakers. I’ll be updating on the meeting through the week, but see the link below for the conference outline.
We’ve been looking at the biochemical characteristics of alpha synuclein in the brains of LRRK2 mutation carriers, with some surprising results. The synuclein in LRRK2 G2019S brains seems to be more soluble than that in idiopathic PD – which could have some important implications for what LRRK2 is doing in PD.
See our paper in Neurobiology of Disease for more details:
A video of the Gretschen Amphlet lecture, presented by myself and Flaviano Giorgini from the University of Leicester, is now on Youtube – see the link below.