Cell and Tissue Research


Alice Price, who just completed a Masters by research in the lab, has a new review out on the LRRK2 signaling system in Cell and Tissue Research. This looks at LRRK2 from a systems biology perspective, putting together a framework for understanding and interpreting how mutations in LRRK2 perturbs the biology of the human brain. Read all about it here:




Antisense therapy and neurodegeneration


I’ve just written a short piece for the conversation on the use of antisense oligonucleotide approaches to target neurodegeneration – following on from recent media reports about a phase 1 clinical trial in Huntington’s disease. A really interesting area of research, and one that has the potential to be relevant for a wide range of diseases.

Read all about it here: https://theconversation.com/antisense-therapy-a-promising-new-way-to-treat-neurological-disease-89006

Paper in Frontiers


Just out in Frontiers in Molecular Neuroscience, a paper from Laura Civiero and the Greggio group (including Susanna, who has been in the lab here in Reading for the last 9 months). This is a really interesting studying of the kinase PAK6, which Laura and Elisa previously linked to LRRK2, demonstrating that it can phosphorylate 14-3-3gamma – read all about it below:


Farewell to Susanna and Clara


We’ve been very fortunate to have two great visiting PhD students – Susanna Cogo from Elisa Greggio’s group at the University of Padova, and Clara Ruz from Raquel Duran’s group at the University of Granada. Both have been working on LRRK2 in some shape or form, and have done some great work – but are now heading back to Italy and Spain respectively. This is the lab saying farewell at the Prince Alfred pub last week – one last taste of British cuisine!

VPS35 Parkinson’s UK PhD Studentship


I’m delighted to announce that myself and Eva Kevei here at the University of Reading have been awarded funding for a three year studentship to investigate how mutations in VPS35 cause Parkinson’s disease. The project will involve working with the nematode worm C.elegans, alongside human cell models, to test what happens when a mutation is present. This is a very exciting project (we’ve just had the genetically engineered – using CRISPR – worms delivered to us). If you want to learn more or apply, click on the link below or email either myself (p.a.lewis@reading.ac.uk) or Eva (e.g.kevei@reading.ac.uk) for more information.